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- Giraja G. Shendage
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Mohite, S. K.
- Drug used in Inflammatory Bowel Disease (IBD) - Brief Review
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal.-Walva, Dist.-Sangli - 415 404, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 6, No 3 (2014), Pagination: 153-161Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract, which includes Crohn's disease (CD) and ulcerative colitis (UC). These diseases have become important health problems. Medical therapy for IBD has advanced dramatically in the last decade with the introduction of targeted biologic therapies, the optimization of older therapies, including drugs such as immunomodulators and 5-aminosalicylic acid (5-ASA), and a better understanding of the mucosal immune system and the genetics involved in the pathogenesis of IBD. The goal of IBD therapy is to induce and maintain remission. Drug delivery to the appropriate site(s) along the gastrointestinal tract also has been a major challenge, and second-generation agents have been developed with improved drug delivery, increased efficacy, and decreased side effect The current treatment paradigm involves a step-up approach, moving to aggressive, powerful therapies only when milder therapies with fewer potential side effects fail or when patients declare themselves to have an aggressive disease. This review focuses on the, symptoms, diagnosis and current treatments for inflammatory bowel disease.Keywords
Inflammatory Bowel Disease (IBD), 5-Aminosalicylates, Corticosteroids, Infliximab, Herbal Drugs, Symptoms, Diagnosis.
References
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- Manning AP, Thompson WG, Heaton KW, Morris AF. Towards positive diagnosis of the irritable bowel. BMJ 1978; 2 (6138): 653-4.
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- McClean, VA, USA: Degnon Associates, 2006. 7 Thompson WG, Irvine EJ, Pare P, Ferrazzi S, Rance L. Functional gastrointestinal disorders in Canada: first population-based survey using Rome II criteria with suggestions for improving the questionnaire. Dig. Dis. Sci. 2002; 47: 225-35.
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- World Gastroenterology Organization, 2009 WGO Global Guideline IBD4
- Barnes PJ, Karin M: Nuclear factor-_B. A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med, 1997, 336, 1066-1071.
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- Francis JA, Raja SN, Nair MG. Bioactive terpenoids and guggulusteroids from Commiphora mukul gum resin of potential anti-inflammatory interest. Chem Biodivers 2004; 1: 1842-1853.
- Saeed MA, Sabir AW. Antibacterial activities of some constituents from oleo-gum-resin of Commiphora mukul. Fitoterapia 2004; 75: 204-208.
- Preparation and Evaluation of Fast Dissolving Tablet Tramadol Hydrochloride
Abstract Views :163 |
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Authors
Rohan Patil
1,
Neha Patil
1,
Aniket Patil
1,
S. J. Shid
1,
V. N. Dange
1,
C. S. Magdum
1,
S. K. Mohite
1
Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
Source
Asian Journal of Pharmacy and Technology, Vol 6, No 3 (2016), Pagination: 183-185Abstract
Novel drug delivery system assists to achieve better patient compliance. Fast dissolving tablets are one of them. FDT have benefits such as accurate dosing, easy portability and manufacturing, good physical and chemical stability and an ideal alternative for pediatric and geriatric patients. FDDT formulation combines the advantage of both liquid and conventional tablet formulation while also offering advantage over both traditional dosage forms. This review gives a view of advantages, limitations, need for formulating FDTS, Formulation factors, excipients used, and methodology and evaluation parameters.
Fast dissolving tablets (FDTs) can be prepared by different methods, such as direct compression, freeze-drying, spray drying, sublimation, wet granulation method4. The basic approach for the development of FDTs is the use of superdisintegrants. The aim of this study was to formulate FDTs with sufficient mechanical integrity and to achieve faster disintegration in the oral cavity without water. To achieve this goal, mannitol used as diluent as well as sweetening agent for the formulation of tablets. Attempts were made to enhance dissolution rate along with faster disintegration using superdisintegrants, like microcrystalline cellulose. Tramadol hydrochloride, a centrally acting synthetic opioid analgesic, was selected as the active pharmaceutical ingredient in the study.
Keywords
Tramadol Hydrochloride, Direct Compression Method, Microcrystalline Cellulose.- Formulation and Optimization of Dermatological Dosage form for Comparative in-vitro Evaluation of Semisolid Bases
Abstract Views :260 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa, Dist-Sangli, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa, Dist-Sangli, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 7, No 2 (2016), Pagination: 46-54Abstract
The aim of this study was to improve the permeation of Diclofenac Sodium. Permeation studies were carried out in - vitro using cellophane membrane. Topical formulations of diclofenac sodium were prepared by using various polymers. Gel, cream and ointment of the drug were prepared with polymers and the formulations were subjected for evaluation. Gel formulations were containing carbopol 940, triethanolamine, and preservatives. Cream was formulated by using stearic acid, glycerin, lanolin and preservatives. Ointment was also formulated by using the ingredients cetostearyl alcohol, hard paraffin, white soft paraffin and wool fat. In-vitro permeation studies by using cellophane membrane in diffusion cell revealed better permeation characteristics of diclofenac sodium. These types of topical dosage forms could give sustained delivery of drug on to the skin, so they are interesting promises to improve skin absorption of non steroidal anti-inflammatory drugs and to prevent side effects associated. The Topical formulations are excellent in the percutaneous absorption of diclofenac or its salts and provide good properties upon use and superior medical effects of diclofenac or its salts.Keywords
Diclofenac Sodium, Gel, Cream, Ointment, Diffusion Cell.- Comparative Standardization Study of Two Marketed Shatavari Churna Formulation
Abstract Views :221 |
PDF Views:1
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon. 415404, IN
1 Rajarambapu College of Pharmacy, Kasegaon. 415404, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 6, No 1 (2016), Pagination: 1-6Abstract
Majority of Ayurvedic practitioners uses traditional herbal preparations for their treatment purposes made by them. So it is necessary to improve safety of herbal drugs by developing certain quality control parameters and by following the WHO guidelines for herbal medicines. Our adulteration. Now days, old methods are necessary but there are lots of limitations to these methods due to shortage of many drugs, unavailability or limited source, adulteration, lack of knowledge of drug identification and adverse effects of drugs etc. Standardization of herbal formulation is essential in order to assess the quality of drugs for therapeutic value. The World Health Organization (WHO) in 1999 has given a detail protocol for the standardization of herbal drugs comprising of a single content, but very little literature is available for the standardization of Shatavari Churna. Two marketed preparations were used for the study. Performed the various parameters including organoleptic characteristics and physicochemical parameters. The set parameters were found to be sufficient to standardize the Shatavari Churna.Keywords
Traditional, Standardization, Shatavari Churna, Physicochemical Parameters.- A Review:Dry Emulsion
Abstract Views :298 |
PDF Views:1
Authors
Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, IN
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, IN
Source
Asian Journal of Pharmaceutical Research, Vol 5, No 4 (2015), Pagination: 208-210Abstract
The dry Emulsion formulation aim to improve the bioavailability of drug substances and reduce their side effects. Dry Emulsions are attractive because they are physically and microbiologically stable formulations. They represent a potential oral drug delivery system for lipophilic and low soluble drug substances. Dry emulsions are prepared by drying liquid o/w emulsions containing a solid carrier in the aqueous phase. The solid carrier provides the dry emulsions with bulk and mass. Dry emulsions can be prepared by spray drying, lyophilization and rotary evaporation. Unfortunately the dry emulsions were cohesive powders. The cohesiveness are reduced by addition of sucrose. For preparing dry Emulsions the organic fillers used are Lactose, Mannitol, Malto-dextrins.Keywords
Dry Emulsion, Lipophilic Drugs, Solid Carriers etc.- Formulation and Evaluation of Itraconazole Emulgel for Topical Drug Delivery
Abstract Views :154 |
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Authors
Affiliations
1 Department of Quality Assurance, Rajarmbapu College of Pharmacy, Kasegaon, Dist: Sangli, Maharashtra, IN
1 Department of Quality Assurance, Rajarmbapu College of Pharmacy, Kasegaon, Dist: Sangli, Maharashtra, IN
Source
Asian Journal of Pharmacy and Technology, Vol 5, No 2 (2015), Pagination: 91-96Abstract
The aim of the present research work was to investigate the potential of emulgel in enhancing the topical delivery of Itraconazole. Emulgel formulations of Itraconazole were prepared using two types of gelling agents namely: Carbopol 934 and Carbopol 940. The influence of the type of the gelling agent and the concentration of both the oil phase and emulsifying agent on the drug release from the prepared emulgel was investigated using a 23 factorial design. The prepared formulations were evaluated for their physical appearance, viscosity, drug release, globule size, skin irritation test, antifungal activity, transmission electron microscopy and stability. Commercially available Itraconazole cream was used for comparison. All the prepared emulgel showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. The antifungal activity and drug release were found to be higher for optimized formulation as compared to the marketed Itraconazole cream. The result of studied revealed that the optimized batch shows 95.08% release in 48 hours and stable for around three. The result of microbial assay compared with marketed product, the result shows46.6% inhibition of optimized batch where as marketed preparation shows only 32.3% inhibition. While result of skin irritation test shows no edema and erythema. No irritation was observed on the skin of the rabbits. Stability studies showed that the physical appearance, rheological study, in vitro drug release, and antifungal activity in all the prepared emulgel remained unchanged upon storage for 3 months. In general conclusion, it was suggested that the emulgel formulation succeed the drug release for sustained drug delivery in a controlled manner in comparison with cream.Keywords
Emulgel, Itraconazole.- A Review on Solid Lipid Nanoparticle
Abstract Views :266 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon Tal-Walwa, Dist Sangli–415 404, IN
1 Rajarambapu College of Pharmacy, Kasegaon Tal-Walwa, Dist Sangli–415 404, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 8, No 3 (2016), Pagination: 218-220Abstract
Solid lipid nanoparticles (SLN) are the emerging field of nanotechnology having many potential applications in drug delivery as well as in research. Lipid nanoparticles offer possibility to develop new therapeutics due to their unique size dependent properties. The ability of incorporating drug molecules into nanocarriers provides a new prototype in drug Delivery which could be used for drug targeting. Therefore solid lipid nanoparticles have great promise for increasing the goal of controlled and site specific drug delivery. Present review focus on broad treatment of solid lipid nanoparticles with their aims, production procedures, advantages, limitations and their possible remedies. SLN are sub-micron colloidal carriers ranging from 50 to 1000 nm, which are composed of physiological lipid, dispersed in water or in aqueous surfactant solution. Solid lipid nanoparticle offer unique properties such as very small size, large surface area, high drug loading and the interaction of phases at the interface and are attractive for their potential to increase performance of pharmaceuticals.- Anti-inflammatory Activity of Aqueous and DCM Extracts of Jatropha gossypifolia Linn in Albino Rats
Abstract Views :175 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, IN
1 Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 4 (2011), Pagination: 148-150Abstract
Medicinal herbs are the local heritage with global importance. World is endowed with a rich wealth of medicinal herbs. The different variety of plants with different therapeutic properties is quiet astonishing. Jatropha gossypifolia Linn (Euphorbiaceae) is a large genus of shrubs, herbs and trees distributed in the tropical parts of the world. A decoction of the bark is used as an emmenagogue, that of the leaves for stomach ache, venereal diseases and as blood purifier. The plant has been used ethnomedically to prevent cancerous growth. The plant is very popular in all Maharashtra and Jatropha gossypifolia Linn has suggested in the Indian system of medicine for number of diseases. The plant is known to possess various active agents such as flavonoids, triterpenoids, sterols (phytosterol), tannins, essential and volatile oils. The anti inflammatory activity of the aqueous and dichloromethane extract of the leaves of Jatropha gossypifolia Linn was investigated with experimental animal model using the carrageenan induced rat paw edema method. The extract 200mg/kg at 240min post treatment caused a significant (p<0.05) reduction in the paw oedema in rats. The effect of the extract was more pronounced at the dose 200mg/kg and was closer to that of ibuprofen 10mg/kg. The finding of the studies indicate that the aqueous extract and dichloromethane extract of leaves of Jatropha gossypifolia Linn had good anti-inflammatory activity in carrageenan induced hind paw edema in rats between 2 to 3 hours.
Keywords
Jatropha gossypifolia Linn, Euphorbiaceae, Antiinflammatory Activity, Carrageenan, Paw Edema.- A Review on Breast Cancer:An Overview
Abstract Views :335 |
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Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon Sangli-415404, IN
1 Rajarambapu College of Pharmacy, Kasegaon Sangli-415404, IN
Source
Asian Journal of Pharmaceutical Research, Vol 7, No 1 (2017), Pagination: 49-51Abstract
Each year more than one million women are diagnosed with breast cancer worldwide over half of whom will die from the disease. Breast cancer is the most common cancer and the leading cause of cancer death for women. Extensive breast cancer screening programmes and the development of new treatments have improved the prognosis of breast cancer overall. However the average year survival rate for women with late stage or advanced breast cancer remains low. On average only 35% of women with advanced breast cancer are alive five years after diagnosis. A third of women are diagnosed with breast cancer at a late stage4 when the disease has a poor prognosis. Treatment options for breast cancer vary depending on the stage at which the cancer is diagnosed. Surgery and radiotherapy are commonly used to treat women with early stage breast cancer. Chemotherapy, hormonal and targeted therapies are frequently used to treat patients with more advanced forms of the disease.Keywords
Breast Cancer, Abnormal Cells, Stages, Diagnosis, Etc.- Formulation and Characterization of fast Dissolving tablets of Perindopril
Abstract Views :175 |
PDF Views:2
Authors
Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon MS, IN
1 Rajarambapu College of Pharmacy, Kasegaon MS, IN
Source
Asian Journal of Pharmacy and Technology, Vol 7, No 1 (2017), Pagination: 51-55Abstract
In this investigation fast dissolving tablets of perindopril were prepared using different superdisintegrants like sodium starch glycolate and crosspovidone by direct compression method. Fast dissolving drug delivery is fastest, safest, convenient and most economic method of drug delivery having the highest patient compliance and preferred over conventional tablets therefore it is currently the gold standard in the pharmaceutical industry. Formulations were evaluated for precompressional parameters bulk density, tapped density, cars index, angle of repose etc and postcompressional parameters like uniformity of weight, thickness, hardness, friability, drug content, wetting time, water absorption ratio, in vitro disintegration time and in vitro dissolution study. The formulation A1 to A3 contain increasing concentration of Sodium starch glycolate showed the increases dissolution rate of drug release from 92.75 to 98.25 in 15 min, whereas formulation B1 to B3 contain crosspovidone in increasing concentration also increases the drug release from 94.75 to 99.02 in 15 min. The drug release from FDTs increased with increasing concentration of superdisintegrants and was found to be highest with formulations containing Crosspovidone as compared to sodium starch glycolate.Keywords
Fast Dissolving, Perindopril, Superdisintegrants, Drug Release Etc.- Formulation and Evaluation of Polyherbal Anti-Acne Gel
Abstract Views :2707 |
PDF Views:1
Authors
A. C. Patil
1,
A. R. Patil
1,
A. C. Patil
1,
S. J. Shid
1,
V. N. Dange
1,
C. S. Magdum
1,
S. K. Mohite
1
Affiliations
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
1 Department of Pharmaceutics, Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Satara, IN
Source
Research Journal of Topical and Cosmetic Sciences, Vol 8, No 2 (2017), Pagination: 61-63Abstract
Acne is an infection of the skin, caused by changes in the sebaceous glands. The most common form of acne is called acne vulgaris, which means "common acne". The redness comes from the inflammation of the skin in response to the infection. One of the most common disorders found among youngsters usually 18-25 years of age is Acne. Acne vulgaris, which is a skin disorder of the pilosebaceous gland leads to the formation of inflammatory lesions, seborrhea etc. There is a remarkable demand of herbal formulations in the global market. Acne is a popular disorder among the teenagers which make them feel unappealing to look at and also a sort of inferior feel. They take many measures to avoid and cure acne. Plants are well known for their medicinal and cosmetic uses.Keywords
Acne, Neem, Nutmeg.References
- Vijayalakshmi A, Tripura A, Ravichandiran V. Development and evaluation of anti acne products from Terminalia arjuna Bark. Int J Pharmtech Research. 3(1) (2011)320-327.
- Goulden Victoria. Guidelines for the management of acne vulgaris in adolescents. Pediatr. Drugs. 5(2003): 301-313.
- Gopal M.G, Farahana B, Dr. Kala Suhas Kulkarni, Effectiveness of Herbal Medication in treatment of Acne vulgaris- A pilot Study, The Indian Practioner; 2001, 54, 10, 723.
- R. S. Adnaik, D. A. Bhagwat, I. D. Raut, S. K. Mohite, C. S. Magdum, Laxative and Anthelmintic potential of cassia alata flower extract, Research Journal of Pharmacy and Technology. Vol-04, No.01, January 2011, 98-100.
- Kanlayavattanakul. M., Lourith N. Therapeutic agents and herbs in topical application for acne treatment. Int. J. Cosmetic Sci. 2011; 33:289-29.